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Mutations at two previously identified loci bag of marbles bam and benign gonial cell neoplasm bgcn prevent progression through spermatogenesis and oogenesis resulting in the overproliferation of undifferentiated germ cells.
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Previously we have identified the bag of marbles bam gene as an intrinsic factor for cystoblast fate in drosophila germline cells and shown that it requires active product from the benign gonial cell neoplasm bgcn gene.
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However in gscs the interplay between genes involved in self renewal versus differentiation remains unclear.
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Schulz ra development cambridge england 138 18 2011 sep.
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Spermatogenesis in drosophila is a model system to identify molecules regulating stem cell lineages.
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Perrimon n developmental cell 28 4 2014 feb 24.
Germ line differentiation factor bag of marbles is a regulator of hematopoietic progenitor maintenance during drosophila hematopoiesis.
Mckearin and ohlstein 1995.
A regulatory network of drosophila germline stem cell self renewal.
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Here we present the cloning and characterization of bgcn.
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The gene bag of marbles bam is an intriguing example of a rapidly evolving reproduction gene having experienced recurrent adaptive evolution in d.
Find the probability of the following event expressing it as a fraction in lowest terms.
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Two intrinsic factors bag of marbles bam and benign gonial cell neoplasm bgcn are required in cystoblasts for their proper differentiation mckearin and spradling 1990.
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